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Pathology General fa8e120d

Coagulative necrosis is seen in:

A
Brain
B
Breast
C
Liver
D
All
High-Yield Explanation
Coagulative necrosis is a form of necrosis in which the underlying tissue architecture is preserved for at least several days after the death of cells in the tissue. The affected tissues take on a firm texture. Presumably, the injury denatures not only structural proteins but also enzymes, thereby blocking the proteolysis of the dead cells; as a result, eosinophilic, anucleate cells may persist for days or weeks. Leukocytes are recruited to the site of necrosis, and the dead cells are ultimately digested by the action of lysosomal enzymes of the leukocytes. The cellular debris is then removed by phagocytosis, mediated primarily by infiltrating neutrophils and macrophages. Coagulative necrosis is characteristic of infarcts (areas of necrosis caused by ischemia) in all solid organs except the brain. Robins 10 th ed P:36

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