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Pathology General fa12436c

Gastrointestinal stromal malignancy arises from which of the following -

A
Smooth muscle
B
Nerve cells
C
Interstitial cells of Cajal
D
Vascular Endothelium
High-Yield Explanation
"Gastrointestinal stromal tumors (GIST) originate from the interstitial cells of Cajal, which controls gastrointestinal peristalsis." On rare occasions, gastric GISTs occur as part of tumor - syndrome, such as :- Carney's trads → Gastric GIST, Paraganglioma and pulmonary chondroma. Neurofibromatosis Type I Histologically, GISTs can be divided into Spindle types → Exhibit spindle cells Epithelioid types → Exhibit epithelioid cells Mixed types → A mixture of both

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