Gastrointestinal stromal malignancy arises from which of the following -
High-Yield Explanation
"Gastrointestinal stromal tumors (GIST) originate from the interstitial cells of Cajal, which controls gastrointestinal peristalsis."
On rare occasions, gastric GISTs occur as part of tumor - syndrome, such as :-
Carney's trads → Gastric GIST, Paraganglioma and pulmonary chondroma.
Neurofibromatosis Type I
Histologically, GISTs can be divided into
Spindle types → Exhibit spindle cells
Epithelioid types → Exhibit epithelioid cells
Mixed types → A mixture of both