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Pharmacology General f9746be0

Drug causing decrease in late sodium current -

A
Nicorandil
B
Ranolazine
C
Trimetazidine
D
Molsidominc
High-Yield Explanation
Ans. is 'b' i.e., Ranolazine o Ranolazine was initially assigned as paial fatty acid oxidation inhibitors. However, now it is believed that it acts by a different mechanism. It acts by blocking a late sodium current that facilitates calcium NCX (Sodium -Calcium exchanger) -4 Calcium overload and decrease left ventricular wall tension --> decreased myocardial oxygen demand.

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