What is DOC of Severe Complicated Falciparum Malaria is ?

AEMESININS : Aemisinin and its three major semisynthetic derivatives in clinical use Dihydroaemisinin, Aemether and Aesunate are potent and Fast-acting Antimalarials. They are optimized for the treatment of Severe P. falciparum malaria and are also effective against the asexual erythrocytic stages of P.vivax. AESUNATE - All patients with Severe Falciparum Malaria should be treated with I/V or I/M Aesunate (atleast 24 hours). The semisynthetic aemisinins have been formulated for Oral (Dihydroaemisinin, Aesunate, and Aemether); Intramuscular (Aesunate and Aemether); Intravenous (Aesunate); and Rectal (Aesunate) routes. AEMETHER - is used only if Parenteral Aesunate is not available PROPEIES : Fastest acting Antimalarial drug Effective against MDR parasites Sho acting C/I in 1st Trimester