Pathology Liver & Biliary Tract f93c6c23

The following features differentiate Rotor syndrome from Dubin Johnson's syndrome EXCEPT

Liver in patients with Rotor syndrome has no increased pigmentation and appears normal

In Rotor syndrome, Gall bladder is usually visualized on cholecystography

Total urinary coproporphyin is substantially increased in Rotor syndrome

Fraction of coproporphyin I in urine is elevated usually more than 80% of the total in Rotor syndrome

High-Yield Explanation

Ans. (d) Fraction of coproporphyrin I in urine is elevated usually more than 80% of the total in Rotor syndrome(Ref: Harrison 18th/Chapter 303)Differentiation between Dubin-Johnson syndrome & Rotor syndrome:CharacteristicDubin-Johnson syndromeRotor syndromePigmentation of LiverPigmented cytoplasmic globulesNot seen; normal histologyTotal urinary coproporphyrin excretionNormalIncreasedFraction of coproporphyrin I/III in urine>80% of total Q<70% of the total QBSP clearanceNormal Q with refluxDelayed Q No reflux

The following features differentiate Rotor syndrome from Dubin Johnson's syndrome EXCEPT

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