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Pharmacology Cytotoxic Anticancer Drugs f922ea87

Which of the following drug can result in cerebellar toxicity?

A
Cyclophosphamide
B
Cisplatin
C
Cytarabine
D
Actinomycin D
High-Yield Explanation
Cytarabine is pyrimidine analogue At higher dose it is known to cause cerebellar toxicity like ataxia, dysahria. other side effects- myelosuppression,mucositis,nausea and vomiting. Cyclophosphamide causes hemorrhagic cystitis Cisplatin is most emetogenic anticancer drug. Actinomycin D and doxorubicin can cause vomiting,stomatitis,diarrhoea,erythema,desquamation of skin,alopecia and bone marrow suppression.

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