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Pharmacology General f8fb55b0

Which of the following inhalational agent should not be used in closed circuit?

A
Desflurane
B
Sevoflurance
C
Both 1 & 2
D
Isoflurane
High-Yield Explanation
Sevoflurane, Trilene & Methoxyflurane are avoided in closed circuit. Sevoflurane reacts with sodalime to produce compound A which is nephrotoxic. Trilene reacts with sodalime and produces phosgene gas and dichloroacetylene which can cause ARDS & seizures respectively. Methoxyflurane can react with rubber tubing of closed circuit.

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