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Unknown General f8f9517c

40-year old female presented with neck swelling. Gross and histology is shown below. What is your diagnosis?

A
Medullary carcinoma thyroid
B
Hashimotos thyroiditis
C
Anaplastic carcinoma
D
Follicular carcinoma
High-Yield Explanation
Ref. Robbins Pathology. 9th edition. Page. 1099 Medullary carcinoma thyroid Gross Single or multiple Typically nonencapsulated Solid, gray / tan / yellow, firm, may be infiltrative Microscopy Round, polygonal or spindle cells in nests, cords or follicles, defined by sharply outlined fibrous bands Tumor cells have granular cytoplasm and uniform round / oval nuclei with punctate chromatin Stroma has amyloid deposits from calcitonin, prominent vascularity with glomeruloid configuration or long cords of vessels, coarse calcifications   IHC – Calcitonin

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