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General Medicine General f86f06ae

The primary defect which leads to sickle cell anemia is –

A

An abnormality in porphyrin part of hemoglobin

B

Replacement of glutamate by valine in β–chain of HbA

C

A nonsence mutation in the β chain of HbA

D

Substitution of valine by glutamate in the a–chain of HbA

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