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Medicine Miscellaneous f80966d2

A 40 year old man having malaise and fatigue, dyspnea on exertion, cardiomegaly on chest X-ray, weight loss of 10 kg, mononeuritis, polyarthritis. The diagnosis is

A
PAN
B
SLE
C
Neuro AIDS
D
Neurosarcoid
High-Yield Explanation
(D) Neurosarcoidosis# NEUROSARCOIDOSIS generally occurs only in cases of sarcoidosis with substantial systemic involvement, and signs of neurologic involvement usually are seen in patients known to have active disease.> Strictly neurologic forms are seen in fewer than 10% of patients; a subset has predominantly neuromuscular involvement.> Definitive diagnosis of neurosarcoidosis requires the exclusion of other causes of neuropathy and the identification of noncaseating sarcoid granulomas by histologic analysis of nerve and muscle biopsy specimens.> Neurological involvement: Papilledema (6%); Cranial neuropathy (59%); Peripheral neuropathy (47%); Mononeuropathy (25%); Myopathy (25%); Psychiatric disorders (19%); Cerebellar ataxia (13%) & Hydrocephalus (6%)

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