Pharyngoconjunctival fever is caused by -

Pharyngoconjunctival fever is caused most commonly by serotypes 3 and 7, but serotypes 2, 4 and 14 also, have been documented as etiologic agents.  Ocular infections caused by Adenovirus - i. Epidemic keratoconjunctivitis → Serotypes 8, 19, 37 ii. Follicular conjunctivitis → Serotypes 3,7 iii. Pharyngoconjunctival fever - Serotypes 3, 7 Adeno Virus  Non-enveloped, DNA (ds DNA) Virus  Has characteristic morphology consisting of an icosahedral shell composed of 20 equilateral triangular faces and 12 vertices → space vehicle appearance.  Human adenovirus grows only in tissue culture of human origins, such as human embryonic kidney, HeLa or HEP-2. The cytopathic effect in tissue culture → cell rounding and aggregation into grape-like clusters.  Adenovirus has been used as a vector for gene therapy.  Adenovirus cause infections of the respiratory tract and eyes and less often of the intestine and urinary tract.  Most frequently affect infants and children  Clinical manifestations □ Most common manifestation in children is an acute upper respiratory tract infection with prominent rhinitis. □ Most common manifestation in an adult is ARDS