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Biochemistry Metabolism of lipid f7a92b58

Which of the following has a Ketogenic effect on liver?

A
Insulin
B
Glucagon
C
GH
D
Androgen
High-Yield Explanation
Physiological Actions of GlucagonGlucagon is the most potent hyperglycemic hormone. It is anti-insulin in nature. Therefore, the net effect is decided by the insulin-glucagon ratio (Fig.24.8).Glucagon is mainly glycogenolytic. The active form of glycogen phosphorylase has formed under the influence of glucagon. Liver is the primary target for the glycogenolytic effect of glucagon.It depresses glycogen synthesis.Gluconeogenesis is ored by glucagon by inducing enzymes like PEPCK, glucose-6-phosphatase, and fructose-1,6-bisphosphatase.Glucagon increases plasma free fatty acid level. In adipose tissue glucagon ors beta-oxidation, as it activates carnitine acyltransferase. The mitochondrial acetyl CoA level increasesKetogenesis is ored.Ref: DM Vasudevan - Textbook of Biochemistry, 6th edition, page no: 284-285

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