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Pharmacology Gastro-Intestinal Tract f7a5ce3e

All of the following are false about Tenapanor except:

A
It is indicated for use in diarrhoea predominant IBS
B
Can be used in children < 6 years
C
Acts by inhibiting NHE3 on enterocytes, reducing reabsorption of sodium in small intestine
D
Constipation is a serious adverse effect
High-Yield Explanation
Tenapanor Small molecule medication approved in September 2019 for the treatment of constipation-predominant irritable bowel-syndrome (IBS-C). MOA - Inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transpoer First and currently only medication within its class By inhibiting NHE3 on the apical surface of the enterocytes, tenapanor reduces absorption of sodium from the small intestine and colon, Resulting in an increase in water secretion into the intestinal lumen, which accelerates intestinal transit time and results in a softer stool consistency. Recommended dosage in adults - 50 mg orally twice daily- prior to breakfast or the first meal of the day and immediately prior to dinner C/I Patients< 6 years of age due to the risk of serious dehydration, Patients with known or suspected mechanical gastrointestinal obstruction

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