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Physiology Endocrine System f729cbfc

True about Laron dwarfism is:

A
Growth hormone deficiency
B
Growth hormone insensitivity
C
Plasma IGF-1 is markedly increased
D
Plasma IGF-BP3 at normal levels
High-Yield Explanation
Laron dwarfism, Plasma GH is normal or elevated GH receptors are unresponsive as a result of loss-of-function mutations of the gene for the receptors. Resultsin growth hormone insensitivity. Plasma IGF-I is markedly reduced, along with IGFBP 3 (IGF-binding protein-3)

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