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Microbiology General f6f40949

About SUPERANTIGENS true is

A
Immune response is increased by 5%
B
Needs to be processed before presentation
C
They are presented by APCs to T cell
D
Directly attached to latrel aspect of TCR beta chain
High-Yield Explanation
Super antigens are molecules that can interact with antigen-presenting cells (APCs) and T-lymphocytes in a non-specific manner.  These antigens do not involve the endocytic processing as required in typical antigen presentation.  Interaction of superantigens with MHC class II molecules of the APC and the V~ domain of the T-lymphocytes receptor activates a large number of T-lymphocytes than conventional antigens.  This leads to massive cytokine expression and immuno-modulation. Staphylococcal enterotoxins, exfoliative toxin and some viral proteins are examples of superantigens. Ref : textbook of microbiology, C P Baveja 5th edition pg no:95

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