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Pharmacology Chemotherapy: General Principles f6790774

A 12-year-old child presents with 4 lesions of leprosy on back and four lesions on left arm. What should be the treatment of this child?

A
once monthly and daily
B
Rifampicin 600 mg once monthly + Dapsone 100 mg daily
C
once monthly + Dapsone 50 mg daily + Clofazimine 50 mg alternate day
D
Rifampicin 450 mg once monthly + Dapsone 50 mg daily
High-Yield Explanation
Ans. (C) (Rifampicin 450 mg + Clofazimine 150 mg) once monthly + Dapsone 50 mg daily + Clofazimine 50 mg alternate day(Ref: National Leprosy Eradication programme)This is a case of multibacillary leprosy. The multi drug therapy for in adults (15 years or above) is Rifampicin 600 mg plus clofazimine 300 mg once monthly and Dapsone 100 mg plus Clofazimine 50 mg daily for 12 monthsAs the patient is child, the doses used are less, rest of the treatment is similarRifampicin 450 mg and Clofazimine 150 mg monthly and dapsone 50 mg daily. As clofazimine less than 50 mg tablet is not available, so 50 mg is given on alternate day.

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