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Pediatrics General f663dd52

Down Syndrome, All are seen except?

A
t(14 ; 21)
B
Trisomy 21
C
t(11 : 14)
D
t (15 :21)
High-Yield Explanation
Ans. is 'c' i.e., t (11:14) In 95% of cases of Down Syndrome - trisomy of 21 Extra chromosome is of maternal in origin 1% have mosaic with 46 chromosomes o 4% have robesonian translocation. t (13 : 21) t(14:21) t (15 : 21) o Very rarely long arm of chromosome 21 is triplicate (Paial trisomy)

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