Acanthosis nigricans is seen with (A)Colonic carcinoma (B)Freckle (C)Squamous cell carcinoma of skin (D)Carcinoma breast

Acanthosis nigricans can also be a reflection of an internal malignancy, most commonly of the adenocarcinoma of the gastrointestinal tract, lung, uterus and breast It appears as velvety hyperpigmentation, primarily in flexural areas. However, in the majority of patients, acanthosis nigricans is associated with obesity and insulin resistance, but it may be a reflection of an endocrinopathy such as acromegaly, Cushing’s syndrome, polycystic ovary syndrome, or insulin-resistant diabetes mellitus (type A, type B, and lipoatrophic forms).