In thromboasthenia there is a defect in -
High-Yield Explanation
Platelet adhesion
Platelet adhesion refers to the binding of platelets to subendothelial matrix.
Platelet membrane glycoprotein Ib - IX is essential for platelet adhesion to subendothelial matrix.
Platelet aggregation
Platelet aggregation refers to adherence of platelets to one another.
Platelet membrane glycoprotein IIb - IIIa helps in aggregation.
Congenital dysfunction of platelet
1. Bernard-Soulier syndrome
Defect in platelet adhesion due to inherited deficiency of glycoprotein Ib - IX.
2. Glanzmann's thrombasthenia
Defect in platelet aggregation due to inherited deficiency of glycoprotein IIb - IIIa.