Which of the following dermatological condition is associated with mutation in K1 (Keratin 1) and K10 (Keratin 10) genes?
High-Yield Explanation
Mutations in keratins K1 and K10 are associated with bullous congenital ichthyosiform erythroderma (BCIE), also sometimes referred to as Epidermolytic hyperkeratosis. Features of Epidermolytic hyperkeratosis: It manifest at bih as generalized erythroderma associated with vesicles and bullae. It then progress to generalized verrucous hyperkeratosis with prominent involvement of flexural areas. Blisters are present in the epidermis.