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Pathology General f5656668

Which of the following dermatological condition is associated with mutation in K1 (Keratin 1) and K10 (Keratin 10) genes?

A
Epidermolysis bullosa simplex
B
Epidermolytic hyperkeratosis
C
Epidermolytic palmoplantar keratoderma
D
Meesmann epithelial corneal dystrophy
High-Yield Explanation
Mutations in keratins K1 and K10 are associated with bullous congenital ichthyosiform erythroderma (BCIE), also sometimes referred to as Epidermolytic hyperkeratosis. Features of Epidermolytic hyperkeratosis: It manifest at bih as generalized erythroderma associated with vesicles and bullae. It then progress to generalized verrucous hyperkeratosis with prominent involvement of flexural areas. Blisters are present in the epidermis.

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