Which of the following chemotherapeutic agents is associated with secondary leukemia-

Ans. is 'c' i.e. Cisplatin "Cisplatin is mutagenic, teratogenic and carcinogenic. Secondary leukemias are repoed with the use of cisplatin and the use of cisplatin or carbolatin based chemotherapy for women with ovarian cancer is associated with a fourfold increased risk of developing secondary leukemia." Remember All alkylating agents can also cause leukemia. Melphalan, nitrosoureas and procarbazine have the greatest propensity, while it is less common with cyclophosphomide.