Which of the following drugs is associated with the untoward side effect of renal tubular damage?

Cisplatin is a highly emetic and nephrotoxic agent. Streptozocin causes the destruction of β-cells of the pancreas and may result in hyperglycemia. Methysergide can cause retroperitoneal fibrosis on long-term use. Cyclophosphamide can result in hemorrhagic cystitis.