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Pediatrics General f4adbaa0

Which of the following is the most common inherited malignancy :

A
Infant leukemia
B
Retinoblastoma
C
Wilm's tumour
D
Neuroblastoma
High-Yield Explanation
"Retinoblastoma is the most strking example of inhirited cancer syndrome. Approximately 40% of retinoblastomas are familial. Carrier of this gene have a 10000 fold increased risk of developing retinoblastoma usualy bilateral". Each child of parent with familial bilateral retinoblastoam has a 50% risk of inheriting the retinoblastoma gene, of these 90% will develop retinoblastoma.

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