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Medicine General f4470ff9

21 yearold female presents with history of mild bilateral ptosis, proximal muscle weakness and easy fatiguability. Which amongst the following, is best in diagnosing this condition: March 2013 (b)

A
Muscle biopsy
B
Edrophonium test
C
Repetitive nerve stimulation test
D
Electromyography
High-Yield Explanation
Ans. B i.e. Edrophonium test Myasthenia gravis Decreased myoneural junction transmission Features: Dysahria, Dysphagia, Proximal muscle weakness, Sensory modalities and deep tendon reflexes are NORMAL MC used cholinergic drugs: Pyridostigmine/neostigmine Surgical procedure (should be done in all cases): Thymectomy

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