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Medicine Infection f430e2c3

Plasmapheresis is treatment of choice for :

A
Henoch scholien purpura
B
Wegener's granulomatosis
C
Good Pasture's syndrome
D
Acute renal transplant rejection
High-Yield Explanation
Ans. is 'c' i.e., Good Pasture's Syndrome Management of Good Pasteur's SyndromeT/t Modalities Are -PlasmapheresisGlucocorticoidsCyclophosphamideAzathioprineMost important t/t is plasmapheresis. To be effective the t/t should be started earlyPlasmapheresis is performed daily or on alternate days until Anti GBM antibodies are not detected in Circulation.T/t of choice for -Wegener's Granulomatosis -Cyclophosphamide with corticosteroidsHenoch Schonlein Purpura -Glucocorticoid (Prednisone 1mg/kg)Acute Renal transplant rejectionTreatment modalities include-High dose steroidsPolyclonal antisera (ATG,ACG)Monoclonal Antibodies(OKT3)PlasmapheresisThe primary treatment is administration of IV methylprednisolone or oral prednisoloneOKT3 - can be given to steroid unresponsive rejections.

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