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Biochemistry Basics of DNA f3fffc4a

Which one of the following bonds links two nucleotides in a nucleic acid?

A
3'-3' phosphodiester bond
B
3'-5' phosphodiester bond
C
5'-5' phosphodiester bond
D
5'-5' phosphotriester bond
High-Yield Explanation
Nucleic acids are directional molecules: 5' end is the end with free (unesterified) phosphate group. 3' end is the end with free OH group. Nucleic acid sequences are written in 5'-3' direction. During the synthesis of nucleic acids, 3' OH group of existing nucleotide is esterified to the 5' phosphoryl group of the incoming nucleotide 3'-5' phosphodiester bond.

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