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Medicine General f3e5ea21

Paraneoplastic opsoclonus myoclonus syndrome is most commonly associated with which malignancy in children?

A
Hepatoblastoma
B
Hepatocellular carcinoma
C
Lymphoma
D
Neuroblastoma
High-Yield Explanation
Opsoclonus is a disorder of eye movement characterized by involuntary, chaotic saccades that occur in all directions of gaze; it is frequently associated with myoclonus and ataxia. Opsoclonus-myoclonus may be cancer-related or idiopathic. When the cause is paraneoplastic, the tumors involved are usually cancer of the lung and breast in adults and neuroblastoma in children. Ref: Harrison's principle of internal medicine 17th edition, chapter 97.

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