If a patient is on Warfarin and INR comes out to be 8. Next step would be to stop the drug and: March 2011

Ans. B: Give oral Vitamin K1 Vitamin K1 is the specific antidote for warfarin Treatment of bleeding due to oral anticoagulants consists of: Withhold the anticoagulant Give fresh blood transfusion; supplies clotting factors and replenishes ost blood. Alternatively fresh frozen plasma may be used as a source of clotting factors Give vit K1 (phytonadione)-specific antidote, but it takes 6-24 hours for the clotting factors to be resynthesized and released in blood after vit K administration.