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Medicine C.N.S. f398c611

Shy dragger syndrome is Parkinsonism + ----?

A
Sensory Neuropathy
B
Motor Neuropathy
C
Cerebellar Ataxia
D
Autonomic Neuropathy
High-Yield Explanation
Ans. D. Autonomic NeuropathyMultisystem Atrophy (Shy Dragger Syndrome)The features are as follows:a. Parkinsonismb. Autonomic neuropathyc. Cerebellar ataxia (due to olivo ponto cerebellar atrophy)d. Additional feature which may be there are - Dystonia, Myoclonus, Emotional incontinence, Sleep deprivation.e. Pathology: There is presence of alpha Synuclein positive inclusion located in the various part of the brain.f. Treatment: Droxidopa is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Unlike norepinephrine and epinephrine themselves, droxidopa is capable of crossing the protective blood-brain barrier (BBB)

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