Drug with Ceiling effect:

B i.e. Buprenorphine Ceiling effect means paicular effect of drug increases with dose of drug, and when the ceiling (roof) is reached fuher incriment in dose not result in increase in effect. Opioid agonist - antagonist compounds produce respiratory depression (& anelgesia) with a ceiling effectQ. which means higher doses do not produce fuher respiratory depression and may actually result in increased ventilation (d/t predominance of antagonist actions)