Inclusion body of CMV is -

Ans. is 'c' i.e., Intranuclear Cytomegalovirus (CMV)* Also known as salivary gland virus* CMV is the largest virus amongst herpes viruses* They are characterized by enlargment of infected cells (cytomegalic cells) and intranuclear inclusions.* Intranuclear inclusion is eccentrically placed and is surrounded by a halo - owl's eye appearance.* Once infected an individual carries CMV for life* CMV is the most common organism causing intrauterine infection.* CMV is the most common pathogen complicating organ transplantation.Clinical manifestations* Most of the infections in immunocompetent persons are asymptomatic.* Clinical features are divided intoA) Congenital infection# Infection is acquired in pregnancy.# It causes cytomegalic inclusion disease. Most common presentation is petechiae, hepatosplenomegaly and jaundice. Other features are microcephaly, cerebral calcification, chorioretinitis, IUGR, prematurity and thrombocytopenia.B) Perinatal infection# Infection is acquired during delivery or postnatally by breast feeding. Most patients are asymptomatic.C) Beyond neonatal period# Most common presentation is heterophile antibody-negative mononucleosis (CMV mononucleosis).D) Immunocompromized host# It causes retinitis, colitis, gastritis, esophagitis, pneumonitis, fever, leukopenia and hepatitis.# Maximum risk of infection after kidney transplant is between 1-4 months after transplantation. Most common presentation is fever, leukopenia and hepatosplenomegaly.# Most common presentation after bone marrow transplantation is interstitial pneumonia.Laboratory diagnosis* Definitive diagnostic test (most specific test) is isolation of virus from urine, saliva, blood or bronchoalveolar washing.* Most sensitive test is PCRfor viral genome (DNA) detection in blood or intraocular fluid (in CMV retinitis).* Serology (IgM or IgG) is not very useful.Treatment* Ganciclovir or valganciclovir are drugs of choice. Foscarnet is used for CMV retinitis.