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Pharmacology General f27ff32b

Cardiotoxicity of bupivacaine -

A
Depressed pacemaker activity
B
Toxic compound damaging myocardial cells
C
Depressed neural control on hea
D
Vascular thrombosis and Myocardial ischemia
High-Yield Explanation
Ans. is 'a' i.e., Depressed pacemaker activity o Local anaesthetics block cardiac sodium channels and thus depress abnormal cardiac pacemaker activity, excitability, and conduction. At extremely high concentrations, local anaesthetics can also block calcium channels.

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