Paraquat poisoning causes

Paraquat poisoning causes Multiple organ failure. Paraquat is a very toxic compound, 2 g can be potentially fatal (10 ml of concentrated 20% solution). Initial signs of toxicity are due to its corrosive effects on the GI tract and Oropharynx. Paraquat absorbed and is sequestered in the lungs--> form hydrogen peroxide and superoxide anions--> cell death-->acute alveolitis. Management providing suppoive care activated charcoal to reduce absorption. Excessive oxygen supplementation can actually increase pulmonary toxicity Oral mucosa is observed with edema, jaundice and ulcerations. bilateral opacities of peripheral and parahilar predominance. Liver enlarged in size and weight, congestive and indurated, gallbladder with cholestasis.