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Medicine All India exam f1773055

"Pellagra" like skin lesion occurs with:

A
Systemic Mastocytosis
B
Bronchial carcinoid
C
Colorectal villous adenoma
D
Medullary thyroid carcinoma
High-Yield Explanation
Carcinoid tumors produce the vasoactive substance, Serotonin.A pellagra-like syndrome is probably caused by diversion of large amounts of tryptophan from the synthesis of Vitamin B3 niacin, which is needed for NAD production, to the synthesis of serotonin and other 5-hydroxyindoles(ref:Harper's 27/e p458)

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