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Maintenance of high urinary pH is impoant during methotrexate treatment because

Bladder irritation is reduced

It decreases renal tubular secretion of methotrexate

Leucovorin toxicity is increased in a dehydrated patient

Methotrexate is a weak acid

High-Yield Explanation

Ref-KDT 6/e p823 Methotrexate is a weak acid and basic reabsorbed in acids urinary PH. Higher plasma concentration may result in toxicity. Therefore to decrease the reabsorptiion through renal tubes urinary pH must be maintained

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Maintenance of high urinary pH is impoant during methotrexate treatment because

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