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All are true predisposing factors for gallstone formation, except:

A
Weight loss leads to mobilization of tissue cholesterol leads to increased biliary cholesterol secretion while enterohepatic circulation of bile acids is decreased
B
Estrogens inhibits hepatic lipoprotein receptors, decrease uptake of dietary cholesterol, and increase biliary cholesterol absorption
C
Gallbladder hypomotility leading to stasis and formation of sludge
D
Clofibrate therapy: Increased biliary secretion of cholesterol
High-Yield Explanation
All others are true. Estrogens stimulate hepatic lipoprotein receptors, increase uptake of dietary cholesterol, and increase biliary cholesterol secretion, and leads to gallstone formation. Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 2618, Table 311-1
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