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Pharmacology Sympathetic System ef6475d3

Alkalinization of urine is required to treat toxicity of all except:

A
Salicylates
B
Barbiturates
C
Amphetamine
D
Methotrexate
High-Yield Explanation
Changes in urinary pH affect tubular reabsorption of drugs that are paially ionized - * Weak bases are ionize more and are less reabsorbed in acidic urine.* Weak acids ionize more and are less reabsorbed in alkaline urine. Urine is alkalinized in barbiturate, methotrexate and salicylate poisoning.

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