Pharmacology Endocrinology ef502042

True about pioglitazone are all except:

Metabolized in the liver by CYP3A4

Selective agonist for the nuclear peroxisome profilerator activated receptor gamma

It causes transcription of gene for carbohydrate and fat metabolism in the absence of insulin

It should be avoided in a patient with cardio-vascular disease

High-Yield Explanation

Pioglitazone cause activation of genes regulating fatty acid metabolism and lipogenesis in adipose tissue contributes to the insulin sensitizing action. (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition, Page No - 270)

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True about pioglitazone are all except:

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