Fluconazole different from ketoconazole in that

REF-KDT6/e p762) Ketoconazole is rarely used now a days because of several limitations. Impoant among them are: Poor oral bioavailability Limited CNS penetration Powerful inhibition of microsomal enzymes Anti-androgenic adverse effects like gynaecomastia Fluconazole is preferred agent because it has Very good oral absorption Maximum CNS penetration (therefore effective in cryptococcal meningitis). No inhibitorv action on microsomal enzymes No anti-androgenic propey.