The earliest change seen in apoptosis is ?

Ans. is 'a' i.e., Cell shrinkageMorphological changes in apoptosis Features of apoptosis are :?1) Cell shrinkage : It is the earliest changes. It is due to damage to cytoskeletal proteins.2) Chromatin condensation (pyknosis)/nuclear compaction : It is the most characteristic feature.3) Formation of cytoplasmic blebs : It is the end stage of apoptosis.4) Cytoplasmic eosinophilia.5) Chromosomal DNA fragmentation : It is due to activity of endonuclease and caspases.6) Formation of apoptotic bodies : These are membrane bound round masses of eosinophilic cytoplasm with tightly packed orgaelles which may contain nuclear debries. Impoant examples of apoptotic bodies are civatte bodies, kamino bodies, councilman bodies, Tingible bodies, sunburn cells, satellite dyskeratotic cells, and eosinophilic globules.7) Phagocytosis of apoptotic cells and bodies by adjacent macrophages or healthy parenchymal cells.8) Considerable apoptosis may occur before it becomes apparent on histological section. Two very impoant differentiating features from necrosis are :?A) Absence of inflammation.B) Intact cell membrane.