Full 2L QBank
Microbiology Immunology ed9ec054

Which of the following statements is true regarding kappa, lambda and heavy chain immunoglobins -

A
Coded in the same site of a chromosome
B
Coded in different sites of same chromosome
C
The chains are formed by genetic rearrangement after maturation
D
Different chains of same immunoglobulins are coded by different chromosomes
High-Yield Explanation
The variable region of each immunoglobulin heavy or light chain is encoded in several pieces--known as gene segments (subgenus). These segments are called variable (V), diversity (D) and joining (J) segments.V, D and J segments are found in Ig heavy chains, but only V and J segments are found in Ig light chains. Multiple copies of the V, D and J gene segments exist and are tandemly arranged in the genomes of mammals. In the bone marrow, each developing B cell will assemble an immunoglobulin variable region by randomly selecting and combining one V, one D and one J gene segment (or one V and one J segment in the light chain). As there are multiple copies of each type of gene segment, and different combinations of gene segments can be used to generate each immunoglobulin variable region, this process generates a huge number of antibodies, each with different paratopes, and thus different antigen specificities.

Related Microbiology MCQs

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now