Nodular regenerating hyperplasia is associated with aEUR'

Drug [Ref: www.ijpmonline.org; Depament of Pathology AFMC Pune D.shelly, MS Tevetial Nodular regenerative hvperplasia Nodular regenerative hyperplasia of the liver is an uncommon condition characterized by diffuse benign transformation of the hepatic parenchyma into small regenerative nodules with minimal or no fibrous septa i.e., "unlike cirrhosis there is absence of fibrosis". It is also known as :? - Nodular transformation - Noncirrhotic nodules - Paial nodular transformation Nodular regenerative hyperplasia belongs to a group of liver diseases that causes an intrahepatic noncirrhotic poal hypeension (NCPHP. In addition to nodular regenerative hyperplasia this group includes incomplete septal cirrhosis and hepatopoal sclerosis. Nodular regenerative hyperplasia is the most common cause of noncirrhotic poal hypeension in the western world and is responsible for 14-27% of cases of NCPH. Conditions associated with nodular regenerative hyperplasia Nodular regenerative hyperplasia has been described in association with a variety of conditions. Most of them are systemic autoimmune diseases or hematological disorders and less frequently solid neoplasms, drugs. Connective tissue disease associated with nodular regenerative hyperplasia Antiphospholipid syndromeQ Felty's syndrome Lupus erythematosis Sjogren's syndrome Systemic sclerosis Hematological disorders associated with Nodular regenerative hyperplasia Usually myeloproliferative disorders Drugs associated with nodular regenerative hyperplasia AzathioprineQ Pathogenesis of nodular regenerative hyperplasia:- Pathogenesis is unceain but seems to be related to abnormalities of hepatic blood flow. The vascular lesions in nodular regenerative hyperplasia could be due to recurrent entbolization of the poal vein radicals by platelet aggregates and thrombi originating in the poal venous system.