Pediatrics New Born Infants ed194376 Anti-histone antibodies are specific for: A CNS lupus B Drug induced lupus C Neonatal lupus D Cutaneous lupus High-Yield Explanation b. Drug induced lupus(Ref: Nelson's 20/e p 1176-1180, Ghai 8/e p 628)Anti histone antibodies are directed against Histones & are seen in Drug-induced lupus.