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Medicine General eceeab45

All are seen in MEN IIA syndrome except

A
Medullary carcinoma of thyroid is seen in 100% of the patients
B
40 - 30% patients have phaeochromocytoms
C
Caused by loss of function mutation in II protooncogene
D
Primary hyperparathyroidism is the most variable feature of MEN II A syndrome
High-Yield Explanation
Answer- C. Caused by loss of function mutation in II protooncogeneMEN-2A or Sipple syndrome, is characterized by pheochromocytoma, medullary carcinoma of the thyroid, and parathyroid hyperplasia.Parathyroid hyperplasia and evidence of hypercalcemia or renal stones.MEN-2A is clinically and genetically distinct from MEN-I and is caused by germline gain-of-function mutations in theRET proto-oncogene on chromosome l0qll.2.40% to 50% have pheochromocytomas.Primary hyperparathyroidism is the most variable feature of MEN 2A syndrome.

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