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Pathology General ecd14ccd

Anaplastic cells often display the following morphologic features except --------.

A
Nuclear-to-cytoplasmic ratio 1:1
B
Retention of polarity
C
Formation of tumor giant cells
D
Quadripolar mitotic figures
High-Yield Explanation
Anaplastic cells often display the following morphologic features: Pleomorphism (i.e., variation in size and shape). Nuclear abnormalities, consisting of extreme hyperchromatism  (dark-staining), variation in nuclear size and shape, or unusually prominent single or multiple nucleoli. Enlargement of nuclei may  result in an increased nuclear-to-cytoplasmic ratio that approaches 1:1 instead of the normal 1:4 or 1:6. Nucleoli may attain astounding  sizes, sometimes approaching the diameter of normal lymphocytes. Tumor giant cells may be formed.  Atypical  mitoses, which may be numerous. Anarchic multiple spindles may produce tripolar or quadripolar mitotic figures.  Loss of polarity. Reference-Robbins BASIC PATHOLOGY 10th edition pg-193

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