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Pathology Cellular Pathology ec8bacc4

Cell swelling is seen in all except?

A
Infection
B
Malignancy
C
Calcification
D
Hypoxia
High-Yield Explanation
Ans. (c) CalcificationRef: Robbiris pathology 9th ed. 140-41, 65* Cellular swelling may occur due to cellular hypoxia, which damages the sodium-potassium membrane pump; it is reversible when the cause is eliminated.* Cellular swelling is the first manifestation of almost all forms of injury to cells.* On microscopic examination, small clear vacuoles may be seen within the cytoplasm; these represent distended and pinched-off segments of the endoplasmic reticulum.* This pattern of non-lethal injury is sometimes called hydropic change or vacuolar degeneration.* The ultrastructural changes of reversible cell injury include: Blebbing blunting, distortion of microvilli, loosening of intercellular attachments, mitochondrial changes, dilation of the endoplasmic reticulum.

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