Most common lobe involved in BPH is

BENIGN PROSTATIC HYPERPLASIA Aetiology Hormones Serum testosterone levels slowly but significantly decrease with advancing age; however, levels of oestrogenic steroids are not decreased equally. According to this theory, the prostate enlarges because of increased oestrogenic effects. It is likely that the secretion of intermediate peptide growth factors plays a pa in the development of BPH Pathology BPH affects both glandular epithelium and connective tissue stroma to variable degrees. These changes are similar to those occurring in breast dysplasia , in which adenosis, epitheliosis and stromal proliferation are seen in differing propoions. BPH typically affects the submucous group of glands in the transitional zone, forming a nodular enlargement. Eventually, this overgrowth compresses the PZ glands into a false capsule and causes the appearance of the typical 'lateral' lobes. When BPH affects the subcervical CZ glands, a 'middle' lobe develops that projects up into the bladder within the internal sphincter. Sometimes, both lateral lobes also project into the bladder, so that when viewed from within, the sides and back of the internal urinary meatus are surrounded by an intravesical prostatic collar. Ref : Bailey and love 27th edition Pgno : 1458