Pharmacology Central Nervous system ec29e130 Mechanism of action of donepezil is: A Centrally acting reversible anticholinesterase B Centrally acting irreversible anticholinesterase C Irreversible cholinergic action D Reversible anticholinesterase High-Yield Explanation donepezil is a centrally acting anti cholinesterase which is reversible.other drugs in this category include rivastigmine Ref; KD Tripathi 8th ed.