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Medicine NEET 2018 eb94691d

Which of the following is true about factor V leiden mutation?

A
Increased bleeding tendency
B
Factor V becomes resistant to cleavage by protein C
C
Arginine to glycine substitution
D
Deficiency of factor V
High-Yield Explanation
Factor V Leiden mutation is hypercoagulable disorder characterized by deep venous thrombosis and pulmonary thromboembolism. Factor V becomes resistant to cleavage by protein C. It occurs due to arginine to glutamate substitution. Factor V deficiency is known as Para hemophilia.

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