Full 2L QBank
Medicine Diabetes Mellitus eacd7dc1

A diabetic normotensive patient of Enterococcus faecalis sepsis, on intravenous Linezolid developed high anion gap metabolic acidosis with increased serum lactate and negative ketone. The acid base abnormality is most probably?

A
Type A lactic acidosis due to septic shock
B
Metabolic acidosis of unceain etiology
C
Diabetic ketoacidosis
D
Type B lactic acidosis due to linezolid
High-Yield Explanation
The given case is of high anion gap metabolic acidosis with increased serum lactate and negative ketones. This rules out choice B and C. Lactic acidosis of type A variety occurs due to poor tissue perfusion and occurs due to Shock or cardiac failure Severe Anemia Mitochondrial enzyme defects Carbon monoxide poisoning, Cyanide poisoning Lactic acidosis of type B occurs due to Malignancies Diabetes Mellitus Renal or hepatic failure Thiamine deficiency Severe Infections (Cholera, Malaria) Seizures Drugs/toxins (biguanides, ethanol, methanol, propylene glycol, isoniazid, and fructose and Nucleoside analogue reverse transcriptase inhibitors in HIV and linezolid) Extra edge Enterococcus Endocarditis E. faecalis >>E.faecium Resistant to many antimicrobial agents Rx--Combination of b-lactam antibiotics with aminoglycoside -Synergistic and bactericidal effects

Related Medicine MCQs

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now